Tom Lloyd, MD, PhD

Johns Hopkins University School of Medicine

Dr. Lloyd is a physician-scientist at Johns Hopkins University specializing in Neuromuscular Degenerative Diseases. He has a broad background in neuroscience and cell biology, beginning with graduate training in Dr. Hugo Bellen’s lab on mechanisms of synaptic vesicle cycling and endosome/lysosome transport in Drosophila. He performed his postdoctoral training in the laboratory of Alex Kolodkin at Johns Hopkins on the generation and characterization of a Drosophila model of Hereditary Motor Neuropathy (HMN7B), and was awarded the Passano Young Investigator award and S. Weir Mitchell Award through the American Academy of Neurology for excellence in neuroscience research. In collaboration with the Rothstein lab, Dr. Lloyd discovered nucleocytoplasmic transport as a fundamental pathophysiological defect in Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD), and other neurodegenerative diseases. Dr. Lloyd’s laboratory utilizes Drosophila melanogaster as the primary model system to investigate the pathogenesis of inherited motor neuron diseases. His laboratory primarily focuses on studying mechanisms of intracellular transport within motor neurons, including axonal transport, nucleocytoplasmic transport, and endolysosomal trafficking, including how these processes are altered in neurodegenerative diseases. Dr. Lloyd currently serves as co-director of the Johns Hopkins Myositis Centers, and specializes in translational and clinical research in Inclusion Body Myositis, a degenerative muscle disease with pathological and clinical overlap with Amyotrophic Lateral Sclerosis (ALS). He has seen over 200 IBM patients who are enrolled into a large prospective clinical study on IBM, one of the largest such cohorts in the country. He was the site PI for the Novartis-sponsored clinical trial of Bimagrumab in sporadic Inclusion Body Myositis and is currently site PI for an FDA/Orphazyme-sponsored of Arimoclomol.


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