Jeffrey K. Rothstein, MD, PhD

Johns Hopkins University

Dr. Rothstein is Professor of Neurology and Neuroscience at Johns Hopkins University.  He is the Founder and Director of the Robert Packard Center for ALS Research and the Director of the Brain Science Institute and the Founder and Co-Director of the ALS Clinic. His  lab first discovered that excitotoxicity might be a common pathophysiological process in sporadic ALS.  His lab in collaboration with Ionis pharma, discovered on the development of antisense oligonucleotides therapy for C9 ALS/FTD patients. He made discoveries on fundamental pathways that underlay familial and sporadic ALS including: excitotoxicity, astroglial dysfunction, oligodendroglial dysfunction and the role of nuclear pore complex and nucleocytoplasmic transport in familial and sporadic ALS. His Answer ALS program combines longitudinal clinical data, at home smartphone data collection and the generation of iPS neurons from each patient, and their comprehensive biological analytics, leading to a data set of 6 billion biological and clinical data points per patient.


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