David Holtzman, MD

Washington University School of Medicine

David Holtzman received his BS (1983) and MD (1985) from Northwestern University followed by a Neurology residency at UCSF from 1985-1989. He did post-doctoral research at UCSF from 1989- 1994. There in addition to his research, he founded a Memory Disorders clinic. He moved to Washington University in 1994 as an Assistant Professor to both start his own lab as well as to get involved in clinical activities and teaching. He was the Chair of Neurology at Washington University from 2003-2021. He is currently Professor of Neurology, scientific director of the Hope Center for Neurological Disorders, and Associate Director of the Knight ADRC. Some of his and his lab’s accomplishments include showing in part how APOE contributes to AD, development of biomarkers for AD, development of CSF biomarkers for AD, demonstration that synaptic activity and sleep affect Aβ and tau levels in vivo, describing the effects of APOE, TREM2, and microglia on tau- mediated neurodegeneration, and development of an anti-Aβ antibody now in a phase III secondary prevention trial for AD (A4) and an anti-tau antibody that completed phase 2 clinical trials for AD and PSP. He has received a number of honors including being a recipient of the Potamkin prize from the American Academy of Neurology for research on Alzheimer’s disease, the MetLife award for Alzheimer’s disease research, election to the National Academy of Medicine of the National Academy of Sciences, election to the National Academy of Inventors, being appointed to the National Advisory council of the NINDS and NIA, the Chancellor’s award for innovation and entrepreneurship and the Carl and Gerty Cori award from Washington University, being elected Fellow of the AAAS, and being the past president of the American Neurological Association. Holtzman has trained over 70 graduate students, post-doctoral fellows, and physician-scientists, many of whom have gone on to successful careers in academia and industry.


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