Conrad "Chris" Weihl, MD, PhD
Washington University in St. Louis
Dr. Weihl, a Professor of Neurology at Washington University School of Medicine in St. Louis, is studying how a cell’s failure to maintain quality control over its proteins – and, especially, to dispose of or reshape deformed and clumped proteins – can lead to degenerative diseases. His focus is a group of rare genetic diseases that cause muscle weakness, bone breakdown and dementia, and he has linked these disease’s diverse signs and symptoms to an inability to properly identify and destroy malformed proteins. His research also supports the idea that snags in the cell’s protein waste-disposal system may contribute not only to normal aging but also to a range of neurodegenerative diseases including Huntington’s disease, Parkinson’s disease and amyotrophic lateral sclerosis, commonly known as Lou Gehrig’s disease.
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