Charbel Moussa, MBBS, PhD
Georgetown University Medical Center
I am an Associate Professor of Neurology at Georgetown University Medical Center (GUMC).. I received a Bachelor of Medicine, Bachelor of Surgery (MBBS), and Doctor of Philosophy (Ph.D) in Biomedical Sciences from the University of Sydney Australia. I am the director of GUMC Translational Neurotherapeutics Program and the Laboratory for Dementia and Parkinsonism (https://sites.google.com/a/georgetown.edu/moussa-lab/home). I serve as the Principal Investigator of the GUMC Lewy Body Disease Association (LBDA) Research Center of Excellence. My expertise is in geriatric neurology with a special focus on movement and memory disorders. I am a neuroscientist focused on the role of tyrosine kinases and de-ubiquitinases on protein ubiquitination and proteasomeautophagy clearance in neurodegenerative diseases. I generated several tyrosine kinase inhibitors (TKIs) that are being investigated as potential therapies for neurodegenerative diseases. I have discovered the potential use of cancer drugs nilotinib (Abl/DDR inhibitor) and bosutinib (Src/Abl Inhibitor) as a treatment for neurodegenerative diseases. I identified a potential novel drug target known as discoidin domain receptor (DDR)-1 that can induce autophagic clearance of misfolded proteins in preclinical and clinical settings. I am a clinical trialist and a translational neuroscience investigator and I have designed and completed a number of Phase I-III clinical trials in Alzheimer’s, Parkinson’s, Dementia with Lewy Bodies (LBD) and Huntington’s disease. I have expertise in epigenomics through next generation whole genome miRNA sequencing in the cerebrospinal spinal fluid (CSF) of Parkinson’s, Alzheimer’s, Dementia with Lewy Bodies and Huntington’s patients that I used to generate a comprehensive database of miRNAs that control autophagy, ubiquitination, the blood brain barrier and inflammation genes. I have wide expertise in the pre-clinical and clinical role of therapeutics and their promising effects on neurodegenerative pathologies. I have published widely in peer reviewed scientific and medical journals on the mechanisms, diagnosis, and treatment of neurodegenerative diseases. I am the co0-founder and Director of the Scientific Advisory Board of clinical stage biotechnology company, KeifeRX LLC that aims to develop TKIs through early and late-stage clinical studies in several neurodegenerative diseases (https://www.keiferx.com)
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