Plenary Session: Hypoxic/Anoxic Injury in the CNS

Date/Time: Tuesday, October 19, 2021 - 2:00 PM – 4:00 PM
Track: Plenary Session
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Description:

In this session, Nobel Prize-winning scientist, Dr. Gregg Semenza will introduce the audience to HIF (hypoxia-inducible factors) that play a role in gene regulation in variable oxygen environments. HIF is instrumental in regulating the transcription of genes involved in adaptive responses to hypoxia, such as glycolysis, erythropoiesis, angiogenesis, and vascular remodeling. There may be therapeutic roles for HIF modulation in cancer therapy, stroke treatment, and management of hypoxic-ischemic encephalopathy in neonates. This session will also touch on ferroptosis and neuronal death as well as post-stroke recovery strategies including novel therapies such as transcortical magnetic stimulation.

Chair: Jennifer Frontera, MD

Co-Chair: Marion Buckwalter, MD, PhD

Objective(s):

  • Understand the role of HIF-1 in gene signaling in different oxygen environments

  • To understand potential future therapeutic interventions involving HIF-1 pathways

  • To understand the role of HIF-1 in neonatal hypoxic ischemic brain injury

Epigenetic Regulation of Abcc8 and Trpm4 is Associated with Intracranial Hypertension and Outcome After Severe TBI

Time: 2:00 PM – 4:00 PM

Harnessing Hypoxic Adaptation to Interdict Ferroptosis and Treat Neurological Diseases

Time: 2:00 PM – 4:00 PM

Hypoxia-Inducible Factors in Physiology and Medicine

Time: 2:00 PM – 4:00 PM

Precision Therapy for Neonatal HI: Role of HIF and Metabolomics

Time: 2:00 PM – 4:00 PM

Transcranial Magnetic Stimulation (TMS) and Post-Stroke Recovery

Time: 2:00 PM – 4:00 PM